Precision Oncology Innovation

IPeR
Interdisciplinary Approaches for
Precision Oncology Research

Developing cutting-edge technological devices and AI algorithms to revolutionize cancer treatment for colorectal cancer, gastric carcinoma, and metastatic melanoma.

€6.8M
Total Investment
30
Months Duration
7
Partner Organizations
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About the Project

Transforming Cancer Care Through Innovation

IPeR aims to create a comprehensive ecosystem of tools that facilitate the creation and management of clinical and molecular analysis chains, from initial tumor diagnosis to the identification of the best candidate drugs.

Our Vision

To provide a comprehensive set of tools that enable the creation and management of clinical and molecular analysis chains, from initial tumor diagnosis to identifying optimal drug candidates through Patient-Derived Organoids (PDO).

Our Mission

To develop innovative technological devices and AI algorithms that simplify the evaluation and implementation of improvements in cancer therapy, focusing on precision oncology approaches.

Expected Impact

Revolutionize precision oncology by enabling personalized treatment strategies, early detection through innovative biomarkers, and improved patient outcomes through data-driven medicine.

Obiettivi Realizzativi (OR)

01

OR 1: Innovative Algorithms

Developing innovative 'Digital Twin' algorithms to solve clinical problems for target pathologies, from microscopic simulation to clinical risk assessment.

02

OR 2: Organ-on-chip

Realization of an advanced platform integrating sensing technologies and fluidics management to leverage bioprinted models for cytotoxicity screening.

03

OR 3: Liquid Biopsy Biomarkers

Quantitative and qualitative analysis of cell-specific microvesicles from liquid biopsies to identify personalized biomarkers for pathology monitoring.

04

OR 4: Clinical Framework

Acquisition of patient datasets for project activities and providing clinical and biological support for validating developed technologies and algorithms.

05

OR 5: Exploitation & Communication

Ensuring exploitation opportunities and integration of results across all project objectives through integrated communication and evaluation.

Core Technologies

Four Technological Pillars

IPeR integrates cutting-edge technologies to create a comprehensive precision oncology platform

AI & Machine Learning
Technology 01

Artificial Intelligence & Machine Learning

Advanced AI algorithms for evaluating Polygenic Risk Scores, identifying target therapy genes, analyzing test results, and making clinical predictions.

  • Polygenic Risk Score evaluation
  • Multi-omic data integration
  • Predictive clinical modeling
  • Drug response prediction
Organ-on-Chip
Technology 02

Next-Generation Microfluidic Devices

Innovative organ-on-chip devices capable of replicating complex tumor microenvironments with parallel organoid growth and continuous temporal analysis.

  • Complex tumor microenvironment replication
  • Parallel organoid cultivation
  • Integrated dedicated sensors
  • Real-time cytotoxicity monitoring
MicroCATCH Platform
Technology 03

MicroCATCH Platform

Proprietary microfluidic platform capable of isolating cell-specific microvesicles from blood for personalized early diagnosis and therapy monitoring.

  • Cell-specific microvesicle isolation
  • Non-invasive liquid biopsy
  • Personalized biomarker development
  • Therapy monitoring capabilities
Digital Twin
Technology 04

Biological & Digital Twins

Integration of biological models (PDO) with digital representations to create comprehensive patient-specific treatment prediction systems.

  • Patient-Derived Organoid (PDO) models
  • Continuous biological monitoring
  • Digital disease modeling
  • Patient-specific predictions
Consortium

Our Partners

A multidisciplinary consortium bringing together excellence in research, technology, and clinical practice

Project Lead

aizoOn

Technology Consulting & AI Development

aizoOn is an independent, global innovation technology and technology consulting company. Its mission is to support clients in the digital era through expertise in technology and innovation.

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Clinical Partner

IRCCS-FPO Candiolo

End-User & Clinical Data Provider

La Fondazione del Piemonte per l’Oncologia, riconosciuta nel 2013 come Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), è un centro specializzato nel trattamento delle patologie oncologiche capace di unire formazione, ricerca di base e applicata, innovazione tecnologica e cura del paziente in un modello di medicina personalizzata per prevenire, diagnosticare, monitorare e combattere il cancro.

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Research Partner

Politecnico di Torino

Organ-on-Chip Development

Politecnico di Torino is one of Italy's oldest and most prestigious public technical universities for engineering and architecture. It is recognized for its strong emphasis on research and collaboration with industries.

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Research Partner

Università di Torino

Clinical & Biological Expertise

Founded in 1404, the University of Turin is one of the oldest and most prestigious Italian universities. It holds a significant role in research and education, recognized for its high-level scientific achievements.

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Industry Partner

BrainDTech

Liquid Biopsy Technology

BrainDTech is an innovative startup dedicated to the early detection and monitoring of neurological diseases. It utilizes a patented method based on microRNA analysis in liquid biopsies to identify disease patterns.

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Industry Partner

Fluody

Fluorescent Molecule Synthesis

Fluody is a chemical Contract Research Organization specializing in synthetic organic chemistry and process development. It offers custom synthesis and contract manufacturing services for the healthcare and life sciences industries.

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Industry Partner

Proplast

Materials & Device Manufacturing

Proplast is a technology center in Italy dedicated to research and innovation within the polymer and composite sector. It integrates industrial and academic expertise to provide materials research and product engineering solutions.

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Clinical Focus

Target Pathologies

Focusing on three major cancer types with significant clinical impact

Colorectal Cancer

Colorectal Cancer

Malignant tumors developing in the colon or rectum, often arising from adenomatous polyps.

PDO Platform Drug Screening Biomarker Discovery
Gastric Carcinoma

Gastric Carcinoma

Cancer originating from the stomach lining, primarily manifesting as adenocarcinomas.

Multi-Omic Analysis Therapy Monitoring Precision Medicine
Metastatic Melanoma

Metastatic Melanoma

Aggressive skin cancer that has spread from the primary site to distal organs or lymph nodes.

Liquid Biopsy Early Detection Treatment Prediction

Innovation Alignment

IPeR aligns with the Piedmont Region's Smart Specialization Strategy 2021-2027, focusing on the Health priority system and contributing to digital transformation and social impact objectives.

Digital Transformation Precision Medicine Data-Driven Healthcare Artificial Intelligence Personalized Therapy Early Detection
Get in Touch

Contact Us

Interested in learning more about IPeR? We'd love to hear from you.

For more information, please contact us at:

info@iper-project.com